The movie starts with Edward "Eddie" Morra (Bradley Cooper), standing on the rooftop of his luxury penthouse. Someone is trying to break into his apartment, as he prepares himself to jump.
Three months earlier, Eddie is a New York City author struggling with writer's block with a deadline looming, and struggling after being dumped by his girlfriend Lindy (Abbie Cornish). One day, Eddie comes across Vernon Gant (Johnny Whitworth), the brother of his ex-wife, Melissa Gant (Anna Friel). Vernon, a drug dealer, offers Eddie a nootropic drug, NZT-48, claiming it allows the user to access 100 percent of his or her brain's capacity instead of the "usual" 20 percent. Eddie accepts the pill and arrives home.
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